Description
NK3 Tachykinin Receptor Cell Line contains U2OS cells stably expressing NK3 Receptor with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual. The NK3 Tachykinin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate NK3 receptor. When a ligand binds to the NK3R, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker NK3 Receptor cell line has been validated measuring calcium concentration changes in the cytosol upon activation with Substance P. The high reproducibility of this assay allows monitoring NK3 Receptor activation process in High Throughput Screening.
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