Description
CB2 Cannabinoid Receptor Cell Line contains HEK293 cells stably expressing CB2 with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual. The CB2 Cell Line allows to assay compounds, or analyze their capability to modulate CB2. When a ligand binds to the CB1, it activates a G protein, which in turn, triggers a cellular response mediated by a second messenger. HiTSeeker CB2 cell line has been validated performing an assay with [3H]CP55940 and increasing concentrations of no radioactive competitor. The high reproducibility of this assay allows monitoring CB2 receptor activation process in High Throughput Screening.
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