Description
CHO-K1 Cell Line Stable Expressing CTLA4 & Luciferase has been developed by stable co-transfection with a human T-lymphocyte-associated protein 4 (CTLA4) and Luc proteins expression plasmids. CTLA4 CHO-K1-luc cell line provides consistent levels of expression of Luc and CTLA4 proteins. This cell line serves as an “in vitro” model for research studies.
CTLA4 (CD152) is a B7/ CD28 family member that inhibits T cell functions. CTLA4 mediates immunosuppression by indirectly diminishing signaling through the co-stimulatory receptor CD28. By limiting CD28-mediated signaling during antigen presentation, CTLA4 increases the activation threshold of T cells, and reduces immune responses to weak antigens such as self- and tumor antigens. Some anti-cancer therapies based in anti-CTLA4 monoclonal antibody therapy has revealed promising results in certain types of cancers, particularly melanoma.
