Immortalized Human Pancreatic Microvascular Endothelial Cells

Description

Immortalized Human Pancreatic Microvascular Endothelial Cells (IM-HPanMEC) have been developed by immortalizing primary human pancreatic microvascular endothelial cells with SV40 Large T antigen.

Immortalized cells were controlled passaging side by side with the primary cells.

• Primary cells go into senescence after the 4th passage;
• the SV40‐tranduced cells go beyond 30 passages.

Each vial of IM-HPanMEC contains more than 1 million viable cells. We also offer optimized medium and reagents for the growth of IM-HPanMEC. They are quality tested together and guaranteed to give maximum performance as a global solution for in vitro IM-HPanMEC culture.

The pancreas is an endocrine gland and digestive organ. It secretes hormones and produces pancreatic juice to aid in digestion. Pancreatic endocrine cells, aka pancreatic islets, produce vital hormones such as glucagon, insulin, amylin, and somatostatin. In order to support the islets, the pancreas is a highly vascularized organ where endothelial cells play a critical role:

• function to transport oxygen and nutrients to the pancreas,
• affect beta cell function and proliferation,
• influence insulin gene expression during islet development,
• produce various growth factors associated with vasoactivity, and
• participate in optimizing blood glucose sensing and regulation.

PanMEC play an important role in the development and progression of pancreatic cancer. Human PanMEC are a useful in vitro model for studying islet biology, pancreatic cancer, transplantation, and regenerative medicine.