Description
Green Fluorescent CCR2 Chemokine Receptor Cell Line contains U2OS cells stably expressing CCR2 tagged with tGFP. These Cell lines proliferate in vitro maintaining fluorescent GPCR expression following the cell culture manual. Innoprot Green Fluorescent CCR2 Chemokine Receptor Cell Line allows to assay compounds, or analyze their capability to modulate CCR2 activation and the following redistribution process inside the cells. When a ligand binds to the CCR2 Receptor, it activates a G protein, which internalizes in big and high intensity vesicles. This cell line has been validated measuring Fluorescent CCR2 redistribution by increase of fluorescence surrounding the nuclei using image analysis algorithms. The high reproducibility of this assay allows monitoring CCR2 Receptor redistribution process in High Throughput Screening.
