Description
ETB Endothelin Receptor Cell Line contains U2OS cells stably expressing ETBR with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual. The ETB Endothelin Receptor Cell Line allows to assay compounds, or analyze their capability to modulate ETBR. When a ligand binds to the ETBR, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. This cell line has been validated measuring calcium concentration changes in the cytosol upon activation with Endothelin agonist. The high reproducibility of this assay allows monitoring ETBR activation process in High Throughput Screening.
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