Description
Alpha1A Adrenergic Receptor (ADRA1A) Cell Line contains U2OS cells stably expressing ADRA1A with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual. The ADRA1A Cell Line allows to assay compounds, or analyze their capability to modulate ADRA1A. When a ligand binds to the ADRA1A, it activates a G protein, which in turn, triggers a cellular response mediated by calcium. HiTSeeker ADRA1A cell line has been validated measuring calcium concentration changes in the cytosol upon activation with epinephrine. The high reproducibility of this assay allows monitoring ADRA1A receptor activation process in High Throughput Screening.
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