Description
Adenosine A2A Receptor Cell Line contains HEK293 cells stably expressing ADORA2A with no tag. HiTSeeker Cell lines proliferate in vitro maintaining GPCR expression following the cell culture manual. The ADORA2A Cell Line allows to assay compounds, or analyze their capability to modulate ADORA2A. When a ligand binds to the ADORA2A, it activates a G protein, which in turn, triggers a cellular response mediated by cAMP. HiTSeeker ADORA2A cell line has been validated measuring cAMP concentration changes in the cytosol upon activation with NECA. The high reproducibility of this assay allows monitoring ADORA2A receptor activation process in High Throughput Screening.
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