Description
The ACE2 stable cell line has been developed by stably transfecting HEK293 cell line with a angiotensin I converting enzyme 2 (ACE2) protein expression plasmid. ACE2 HEK293 cell line provides consistent levels of expression of human ACE2 protein in cells surface. Each vial of cells contains more than 3 million viable cells stably expressing ACE2 with hygromycin resistance gene.
ACE2 stable expressed HEK293 Cell line is ready to use in cell-based assay applications, such as Screening for ACE2 inhibitors. This stably transfected clonal cell line provides consistent levels of expression, which helps simplify the interpretation of results. ACE2 HEK293 Cell line also allow to establish in vitro models for High Throughput and High Content Screening.
Angiotensin I converting enzyme 2, a.k.a. ACE2, is a carboxypeptidase that potently degrades angiotensin II to angiotensin 1–7. It also plays a key role in the renin-angiotensin system (RAS). The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility.
In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). ACE2 cell line allows the study of SARS-CoV-2 spike/ACE2 interaction in cell-based assays.
Cell Online also offers many other stale cell line and primary cells for COVID-19 research. Check the list.
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